1168-163 High frequency ultrasound thrombolysis: In vitro effects of ultrasound mode, duration, temperature, and frequency
نویسندگان
چکیده
منابع مشابه
Dual frequency ultrasound-enhanced tissue plasminogen activator thrombolysis in an in vitro human clot model
Introduction: Stroke causes death and disability in patients throughout the world. At present, the only FDA- approved drug for ischemic stroke is recombinant tissue plasminogen activator (rt- PA). Unfortunately, rtPA can cause intracerebral hemorrhage and must use within limited time window (within 3-4.5 hour after onset of stroke). Ultrasound with rtPA loaded liposomes (rtPA_L...
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Vascular occlusion by the thrombi is the main reason for ischemic stroke and deep vein thrombosis. High-intensity focused ultrasound (HIFU) and histotripsy or microtripsy pulses can effectively dissolve the blood clot with no use of thrombolytic agent and ultrasound contrast agent (microbubbles). In this study, HIFU bursts at the same duty cycle (2%) but varied pulse repetition frequency (PRF) ...
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Ultrasound imaging is proving to be an important tool for medical diagnosis of dermatological disease. Backscatter spectral profiles using high-frequency ultrasound (HFUS, 10-100 MHz) are sensitive to subtle changes in eukaryotic cellular morphology and mechanical properties that are indicative of early apoptosis, the main type of cell death induced following photodynamic therapy (PDT). We perf...
متن کاملThickness mode high frequency MEMS piezoelectric micro ultrasound transducers
Thickness mode piezoelectric micro-electromechanical system (MEMS) ultrasound transducers, operating in the 50-75 MHz range, have been fabricated using a composite sol gel technique in combination with wet etching. The composite sol gel technique involves producing a PZT powder/sol composite slurry, which when spun down yields films a few micrometers thick. Repeated layering, and infiltration, ...
متن کاملQuantification of Ultrasound Contrast Agents Using High Frequency Ultrasound
Ultrasound contrast agents (UCAs) are small microbubbles filled with gas. Because of their scattering properties, UCAs enhance the diagnostic capabilities of ultrasonic imaging. UCAs are associated with therapeutic or enhancing therapeutic applications of ultrasound and with possible adverse bioeffects. Quantification of the in vivo concentration of microbubbles is therefore essential to establ...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2004
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(04)91543-4